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Click through the PLOS taxonomy to find articles in your field. Download: PPT. Figure 1. Figure 3. Reduced spreading defect of keratinocytes from old hpm mice. The defects of epidermal hpm keratinocytes ameliorate with age In agreement with the external appearance Figure 1E , histology of skin sections from 6. Figure 4. Figure 5. Figure 6.
Figure 7. Generation of mutant mice Mouse genomic clones used to generate the targeting construct were described earlier . Flow cytometry Freshly isolated keratinocytes 0. Supporting Information. Figure S1. Figure S2. Figure S3.
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Acknowledgments We thank Drs. Roy Zent and Ambra Pozzi for carefully reading the manuscript. References 1.
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Cancer Metastasis Rev — View Article Google Scholar 2. Nature — View Article Google Scholar 3. Watt FM Role of integrins in regulating epidermal adhesion, growth and differentiation. Embo J — View Article Google Scholar 4. Nat Genet — View Article Google Scholar 5.
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by Zac Halter
Development — View Article Google Scholar 9. Jones PH, Watt FM Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell — View Article Google Scholar Cell 83— Jensen UB, Lowell S, Watt FM The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis. J Cell Sci — Carroll JM, Romero MR, Watt FM Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis.
Romero MR, Caroll JM, Watt FM Analysis of cultured keratinocytes from a transgenic mouse model of psoriasis: effects of suprabasal integrin expression on keratinocyte adhesion, proliferation and terminal differentiation. Experimental Dermatology 8: 53— Nat Biotech — Ocogene — Genes Dev 9: — Genesis 52— J Biol Chem — Circ Res — Science — Lechler T, Fuchs E Asymmetric cell divisions promote stratification and differentiation of mammalian skin.
BioEssays — COM would be more than pleased to invite the federal court system to review the underlying, unconstitutional concealed carry ban that sparked this unfortunate situation. The most persuasive and binding guidance available on concealed carry in schools comes from the U. Supreme Court case D.
Heller , in which the court majority determined that the Second Amendment protects a fundamental, individual right to keep and bear arms, disconnected from militia service. For evidence of this, we need only look at the decision arrived at in Duncan v. Becerra by U. Benitez of the Southern District of California on March 29, In the context of the aforementioned case, now pending before the U. It fits like a burlap bag. It is a single-dimensional, prophylactic, blanket thrown across the population of the state. Mance v. Sessions , F. Instead it is a categorical ban on acquisition and possession for all law-abiding, responsible, ordinary citizens.
Categorical bans are the opposite of narrowly tailored bans. Why, for instance, if a citizen completes the rigorous FASTER program out of Ohio — which mandates that licensees outperform duly-appointed state police officers on their qualification exam and pass stringent scenario-based active killer response and medical training — is said citizen subject to a total ban on carrying their duly licensed weapon onto public school property?
The answer is that said blanket, non-narrowly tailored ban simply feeds the moral indignation of Buffalo and New York State progressives who believe that the state should hold a monopoly on defensive force inside public schools, not because any reliable data indicates that such a ban translates into safer schools for students.